Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue 8, Pages 541-544Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2006.11.007
Keywords
tardive dystonia; deep brain stimulation; globus pallidus internus
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We report a rapid, dramatic and sustained improvement following bilateral pallidal stimulation in two patients affected by intractable generalized tardive dystonia. Both patients had a chronic psychiatric disorder and developed chronic disabling generalized dystonic symptoms persisting despite prolonged withdrawal of neuroleptics and all available symptomatic treatment. The clinical benefit in both patients persisted throughout all the follow up period of 13 and 7 months. The favorable and prolonged response in our two patients suggests that deep brain stimulation may be an effective treatment for medically refractory tardive dystonia. (c) 2006 Elsevier Ltd. All rights reserved.
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