Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 13, Issue 12, Pages 3491-3500Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200601205
Keywords
photodynamic therapy; porphyrins; self-assembly; singlet oxygen; two-photon absorption
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We have synthesized a novel, two-photon-absorbing photosensitizer for two-photon-absorption photodynamic therapy (2PA-PDT). The molecule is a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers connected through Zn-imidazolyl self-assembly and covalently linked through olefin metathesis. It has an effective two-photon-absorption (2PA) cross-section value, sigma((2)), of 33 000 4600 GM with 5-ns pulses at 890 nm measured by using the open-aperture Z-scan technique. The compound was found to generate singlet oxygen, cytotoxic for tumor cells in photodynamic therapy (PDT), under 2PA conditions by conducting photobleaching experiments with anthracene-9,10-dipropionic acid sodium salt (ADPA).
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