Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue -, Pages S276-S280Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(08)70016-6
Keywords
pedunculopontine nucleus; Parkinson's disease; surgery; deep brain stimulation; gait; postural instability; axial symptoms
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The pedunculopontine nucleus (PPN) is a brainstem locomotive center that also processes sensory and behavioral information. Through its connections with basal ganglia structures and the spinal cord, the PPN may play a role in axial motor symptoms in Parkinson's disease (PD). We review the anatomical features of the PPN, its role in motor control, and its potential role as a target for PD surgery, including the results of recently published clinical studies. (C) 2007 Elsevier B.V. All rights reserved.
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