Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 42, Issue 1, Pages 12-18Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2006.09.009
Keywords
reperfusion injury; adenosine; opioids; postconditioning; heart; ischemia/reperfusion
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Funding
- NHLBI NIH HHS [R01 HL08311, R01 HL60051, R01 HL07707, R01 HL008311, R01 HL077707, R01 HL060051-09, R37 HL074314-04, R01 HL077707-03, R01 HL060051] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL008311, R01HL077707, R37HL074314, R01HL060051] Funding Source: NIH RePORTER
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It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se, still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: 'postconditioning' (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway. (c) 2006 Elsevier Inc. All rights reserved.
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