Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 13, Issue 31, Pages 8801-8810Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200700129
Keywords
chemical biology; click chemistry; dendrimers; functionalization
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A straightforward methodology for the synthesis of multifunctionalized dendrimers that is based on an orthogonal functionalization strategy has been developed. Polyamide-based dendrimers that possess both a single aldehyde and a single azide moiety on their periphery have been synthesized by using a convergent synthetic strategy. These dendrimers can be functionalized quantitatively with small organic and biological molecules that contain hydrazide and/or alkyne groups in which each functional moiety is completely specific for its complementary motif. This orthogonal functionalization strategy has the potential to be used to synthesize multifunctional dendrimers for a variety of applications, which range from targeted biological delivery vehicles to optical materials.
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