Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue 8, Pages 509-515Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2007.04.003
Keywords
Parkinson's disease; LRRK2; dardarina; Spain; mutation
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Funding
- NINDS NIH HHS [P50 #NS40256] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS040256] Funding Source: NIH RePORTER
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Herein we describe a comparative clinical and genetic study of Lrrk2-associated parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and G2019S account for 15 out of 50 kindreds (30%) with familial Parkinson's disease. We observe common founder haplotypes for both R 1441 G and G2019S carriers. Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas. (c) 2007 Elsevier Ltd. All rights reserved.
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