Journal
CHROMOSOME RESEARCH
Volume 15, Issue 5, Pages 633-651Publisher
SPRINGER
DOI: 10.1007/s10577-007-1143-0
Keywords
chromosome homology; meiosis; meiotic silencing; prophase 1; recombination; trans-sensing
Funding
- NIGMS NIH HHS [R01 GM058770, GM58770, R01 GM063102, GM63102] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063102, R01GM058770] Funding Source: NIH RePORTER
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The sensing of accurate homologous recognition and pairing between discreet chromosomal regions and/or entire chromosomes entering meiosis is an essential step in ensuring correct alignment for recombination. A component of this is the recognition of heterology, which is required to prevent recombination at ectopic sites and between non-homologous chromosomes. It has been observed that a number of diverged organisms add an additional layer to this process: regions or chromosomes without a homologous counterpart are targeted for silencing during rneiotic prophase I. This phenomenon was originally described in filamentous fungi, but has since been observed in nematodes and mammals. In this review we will generally group these phenomena under the title of. meiotic silencing, and describe what is known about the process in the organisms in which it is observed. We will additionally propose that the functions of meiotic silencing originate in genome defense, and discuss its potential contributions to genome evolution and speciation.
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