Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue -, Pages S309-S315Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(08)70022-1
Keywords
Parkinson's disease model; environmental factor; LRRK2; alpha-synuclein; MPTP; rotenone
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Funding
- PHS HHS [16375] Funding Source: Medline
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PD is the second most common neurodegenerative disease, and affects 5% of the population by the age of 85. PD is a multi-factorial disease with a complex etiology including genetic risk factors, environmental exposure and aging. The pathogenesis is not fully understood. Here we review research on the genetic and evironmental causes of PD and the Current research models. None of the single models replicate all the features of PD. Genetic models (possibly including more than one mutation) in combination with toxins or other environmental manipulation may provide better models of PD pathogenesis. (C) 2007 Elsevier B.V. All rights reserved.
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