Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 387, Issue 2, Pages 469-479Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-006-0964-6
Keywords
quorum-sensing; Pseudomonas aeruginosa; virulence; regulation
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007285] Funding Source: NIH RePORTER
- NIAID NIH HHS [5T32AI07285, R37AI37713] Funding Source: Medline
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Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several layers of regulation within the QS-circuit. To address this complexity, mutations in genes encoding known or putative transcriptional regulators that were also identified as being regulated by the las and/or rhl QS systems were screened for their contribution in mediating several phenotypes, for example motility, secreted virulence products, and pathogenic capacity in a lettuce leaf model. These studies have further elucidated the potential contribution to virulence of these genes within the QS regulon.
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