fMRI at 7 T: Whole-brain coverage and signal advantages even infratentorially?

fMRI is one of the most likely applications to benefit from high field MRI. It profits from the higher signal-to-noise ratio (SNR) and increased BOLD contrast itself. However, this sensitivity to susceptibility brings with it problems, e.g. in-plane dephasing and signal dropouts near tissue-air boundaries. Therefore, most fMRI studies at 7 T focus on high resolution in supratentorial areas. Nine volunteers were measured at both 1.5 and 7 T using finger tapping with fMRI in a block design fashion. An EPI sequence with short TE (28 ms at 7 T) was chosen for covering the whole brain. A CP transmit/receive head coil was used for image acquisition. Statistical analyses were performed using SPM 02. The activated images were superimposed on both individual images and a standard TI-normalized brain dataset. All cerebral areas involved in finger tapping could be revealed using 7 T: S1, Ml, SI, SMA, thalamus, and cerebellar areas. At 1.5 T the activation in the thalamus was only detectable in one subject using the same corrected p value for all analyses. Furthermore, the BOLD signal change was significantly higher at 7 T than at 1.5 T (factor 2 to 3). A well fitted response curve could be detected in all sensory-motor areas at 7 T in whole-brain coverage, even in areas suffering from susceptibility like the cerebellum. Supra- and infratentorial sensory-motor areas are consistently and reliably detectable using whole-brain fMRI at 7 T with good quality response functions and, as expected, higher signal compared to 1.5 T. (c) 2007 Elsevier Inc. All rights reserved.