Long-term follow-up after neoadjuvant chemotherapy for high-risk cervical cancer during pregnancy

Background. We report on a patient with a high-risk cervical cancer during pregnancy treated with neoadjuvant chemotherapy (NACT) followed by radical surgery. Case. A 38-year-old woman was diagnosed with FIGO stage IIA cervical cancer at 19 weeks' gestation. She received four cycles of cisplatin (50 mg/m(2)) and vincristine (1 mg/m(2)) at 3-week intervals starting at 23 weeks' gestation. A cesarean section with radical hysterectomy and pelvic lymphadenectomy was performed at 33 weeks, delivering a 1920 g male newborn. Histology showed a poorly differentiated squamous cell carcinoma with lymph vascular invasion and pelvic lymph node metastases. The patient received three farther cycles of chemotherapy. Both mother and child are healthy at 80 months after the primary diagnosis. Conclusion. NACT followed by radical surgery may be effective in selected patients with invasive cervical cancer during pregnancy. (c) 2007 Elsevier Inc. All rights reserved.