Journal
VIROLOGY
Volume 359, Issue 1, Pages 190-200Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.09.023
Keywords
interferon; paramyxoviruses; PIV5; mda-5; RIG-I; V proteins
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/00115/2, BBS/B/00662, BBS/B/00344] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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The induction of IFN-beta by the paramyxovirus PIV5 (formerly known as SV5) is limited by the action of the viral V protein that targets the cellular RNA helicase mda-5. Here we show that 12 other paramyxoviruses also target mda-5 by a direct interaction between the conserved cysteine-rich C-terminus of their V proteins and the helicase domain of mda-5. The inhibition of IFN-beta induction is not species-restricted, being observed in a range of mammalian cells as well as in avian cells, and we show that the inhibition of mda-5 function is also not restricted to mammalian cells. In contrast, the V proteins do not bind to the related RNA helicase RIG-I and do not inhibit its activity. The relative contributions of mda-5 and RIG-I to IFN-beta induction are discussed. (c) 2006 Elsevier Inc. All rights reserved.
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