Journal
INFECTION AND IMMUNITY
Volume 75, Issue 1, Pages 527-530Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00732-06
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Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000095] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL077460, R01HL083839] Funding Source: NIH RePORTER
- NCRR NIH HHS [5M01 RR 00095, M01 RR000095] Funding Source: Medline
- NHLBI NIH HHS [R01 HL83839-01, HL R21077460-01, R01 HL083839] Funding Source: Medline
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Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.
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