Journal
JOURNAL OF DRUG TARGETING
Volume 24, Issue 6, Pages 492-502Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1061186X.2015.1108325
Keywords
Mitochondria-targeted; multifunctional; multilevel targeting; nanomedicine; peptides
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Funding
- National Natural Science Foundation of China [81473147, 81274100]
- Collaborative Innovation Center of Chinese Medicinal Resources Industrialization [ZDXM-2-3]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) - Qing Lan Project, Six talent peaks project in Jiangsu Province, Outstanding talent training program of Nanjing University of Chinese Medicine of Pharmacy
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Mitochondria are one type of the major organelles in the cell, participating in a variety of important physiological and biochemical processes, such as tricarboxylic acid cycle, fatty acid metabolism and oxidative phosphorylation. Meanwhile, it also happens to be the key regulator of apoptosis by triggering the complex cell-death processes through a variety of mechanisms. Since it plays a pivotal role in cell-death, a mitochondria-targeted treatment strategy could be promising for cancer therapy. In this comprehensive review, we focused on the mechanisms of mitochondrial targeting and a variety of strategies to realize the purpose of mitochondrial targeting, including that based on the use of lipophilic cations, and mitochondrial targeting signal peptides (MTS) as well as cell-penetrating peptides (CPPs). Then on this basis we present some several developed strategies for multifunctional mitochondria-targeted agents so as to achieve the good anti-cancer therapeutic effects.
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