Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers

Papers from a generation ago suggested that phenothiazines - in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia - downregulate the epidermal growth factor receptor. As numerous cancers - e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma - are dependent on signaling via this receptor, we here suggest that phenothiazines such as trifluorperazine be considered for use in epidermal growth factor receptor associated cancers. (c) 2007 Elsevier Ltd. All rights reserved.