Journal
ORAL ONCOLOGY
Volume 43, Issue 1, Pages 37-41Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2005.12.027
Keywords
endothelin; ET-1; saliva; oral cancer; oral squamous cell carcinoma
Categories
Funding
- NATIONAL CANCER INSTITUTE [R21CA095231, R33CA095231] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [K12DE014609, K23DE000443, P01DE013904] Funding Source: NIH RePORTER
- NCI NIH HHS [CA095231] Funding Source: Medline
- NIDCR NIH HHS [K23DE00443, DE14609, P01DE13904] Funding Source: Medline
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The analysis of saliva has been proposed as a potentially rapid, non-invasive method to monitor and diagnose patients with oral disease. In this study we measured salivary endothelin-1 (ET-1) levels in patients diagnosed with oral squamous cell carcinoma (SCC) prior to treatment. We demonstrate significantly elevated salivary ET-1 levels in the oral SCC group (4.37 +/- 1.35 pg/ml), relative to the control group (1.16 +/- 0.29 pg/ml). ET-1 and ET-1 mRNA were also measured in oral SCC tissue specimens and compared to normal oral epithelial controls. The concentration of ET-1 in the oral SCC specimens was 17.87 +/- 4.0 pg/ml and in the normal epithelial controls the concentration of ET-1 was 5.43 +/- 2.5 pg/ml. ET-1 mRNA was significantly overexpressed in 80% (8/10) of the oral SCC specimens. Our results demonstrate the potential utility of salivary analysis for ET-1 levels to monitor patients at risk for oral SCC. (c) 2006 Elsevier Ltd. All rights reserved.
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