Journal
GENETICS
Volume 175, Issue 1, Pages 7-16Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.106.069963
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067761] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM067761] Funding Source: Medline
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RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the approach. Further, to demonstrate the versatility of the technology, we provide examples of the various applications of the method to problems in signal transduction and cell and developmental biology. Finally, we discuss emerging technological advances that will extend RNAi-based screening methods.
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