Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 13, Issue 1, Pages 2-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2006.10.020
Keywords
chronic graft-versus-host disease; immunology; response criteria; therapy
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Funding
- Intramural NIH HHS Funding Source: Medline
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Clinical research into chronic graft-versus-host disease (GVHD) lags behind that in other areas in the field. Interest in chronic GVHD has increased significantly in recent years for various reasons, including advances in biotechnology, a perceived increase in the incidence of chronic GVHD, and decreased regimen-related mortality, resulting in a new emphasis on quality of life and absence of disability as endpoints of major significance in transplantation survivors. In this overview, we address 3 key areas related to chronic GVHD that hold the highest promise for major advances in the near future: pathobiology, response criteria, and therapy. (c) 2007 American Society for Blood and Marrow Transplantation.
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