Journal
BIOMATERIALS
Volume 28, Issue 1, Pages 99-107Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.08.030
Keywords
poly(methyl methacrylate); poly(N-isopropylacrylamide); star block copolymer; micelle; thermosensitivity; controlled drug release
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A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(Nisopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in water, which was confirmed by FT-IR, H-1 NMR and fluorescence spectroscopy. Transmission electron microscopy images showed that these nanoparticles were regularly spherical in shape. The micelles showed reversible dispersion/aggregation in response to temperature cycles through an outer polymer shell lower critical solution temperature (LCST) for PNIPAAm at around 34 degrees C, observed by optical absorbance measurements. Resulted polymeric micelles loaded with prednisone acetate showed a much improved drug release behavior due to the special micellar structure. (c) 2006 Elsevier Ltd. All rights reserved.
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