Journal
BIORESOURCE TECHNOLOGY
Volume 98, Issue 12, Pages 2313-2320Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2006.09.014
Keywords
Escherichia coli; polyhydroxyalkanoates; metabolic engineering; polyester; production
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Polyhydroxyalkanoates, the natural polyester that many microorganisms accumulate to store carbon and reducing equivalents, have been considered as a future alternative of traditional plastic due to their special properties. In Escherichia coli, a previous non-polyhydroxyalkanoates producer, pathway engineering has been developed as a very powerful approach to set up microbial production process through the introduction of direct genetic changes by recombinant DNA technology. Various metabolic pathways leading to the polyhydroxyalkanoates accumulation with desirable properties at low-cost and high-productivity have been developed. At the same time, high density fermentation technology of E coli provides an efficient polyhydroxyalkanoates production strategy. This review focused on metabolic engineering, fermentation and downstream process aiming to polyhydroxyalkanoates production in E coli. (C) 2006 Elsevier Ltd. All rights reserved.
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