Use of oral corticosteroids and the risk of acute myocardial infarction

Introduction: A few epidemiological studies suggested an increased coronary heart disease (CHD) risk with high doses of oral corticosteroids. Methods: We performed a cohort study with nested case-control analysis to estimate the risk of acute myocardial infarction (AMI) associated with the use of oral corticosteroids by dose and duration. We followed-up 404,183 persons, 50-84 years old, without cancer from the general UK population. After validation of a random sample (confirmation rate of 96%), we included 4795 hospitalised cases of AMI or CHD deaths. We randomly sampled 20,000 controls, frequency matched by sex, age and calendar year. Relative risks were estimated using unconditional logistic regression. Results: The adjusted OR for AMI in current users of oral corticosteroids compared to non-users was 1.42 (95% CI: 1.17-1.72). The risk during the first 30 days of use (OR= 2.24; 95% CI: 1.56-3.20) was greater than with longer duration (OR= 1.22; 95% CI 0.98-1.52). The risk was more pronounced (OR= 2.15; 95% CI 1.45-3.14) among users of prednisolone equivalent doses > 10mg/day. The dose effect was observed both among patients with and without CHD or COPD/asthma. Conclusion: These results suggest a small increased risk of AMI with oral corticosteroid use with a greater risk observed among users of high corticosteroid dose. (c) 2006 Elsevier Ireland Ltd. All rights reserved.