Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 5, Issue 4, Pages 670-679Publisher
WILEY
DOI: 10.1111/j.1538-7836.2007.02408.x
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Funding
- NHLBI NIH HHS [R01 HL078663, HL070304, K08 HL070304, P50 HL054469, HL078663, R01 HL074219, HL074219] Funding Source: Medline
- PHS HHS [54469, 19278] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL074219, P50HL054469, K08HL070304, R01HL078663] Funding Source: NIH RePORTER
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Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis.
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