Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 21, Issue 7, Pages 1255-1263Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.2938
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Many formulated products contain complex polymeric excipients such as polyethylene glycols (PEGs). Such excipients can be readily ionized by electrospray and may be present at very high concentrations, thus making it very difficult to identify trace level impurities such as degradants in samples, even if hyphenated techniques such as liquid chromatography/mass spectrometry (LC/MS) are used. Ion mobility (IM) spectrometry is a very rapid gas-phase separation technique and offers additional separation capability within the LC timeframe. This work investigates the use of an IM separator in combination with high-pressure liquid chromatography (HPLC) and MS, to improve the separation of drug-related materials from excipients, thus aiding the identification of trace-level impurities in an anti-HIV medication, Combivir. Copyright (c) 2007 John Wiley & Sons, Ltd.
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