Journal
CELL CYCLE
Volume 6, Issue 1, Pages 3-7Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.6.1.3593
Keywords
Raf-1; B-Raf; PP1; PP2A; PP5; 14-3-3; dimerization; feedback phosphorylation; signal transduction
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The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events-relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling.
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