Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 21, Issue 13, Pages 2039-2045Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.3059
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Ultra-performance liquid chromatography (UPLC) coupled to orthogonal acceleration time-of-flight mass spectrometry (oa-TOFMS) in positive electrospray ionization mode was used to obtain metabolite profiles for urine obtained from three strains of Zucker rat. These were the Zucker lean, the Zucker (fa/fa) obese and the Zucker lean/(fa) cross. Clear age- and strain-related differences were noted with the leptin-deficient (fa/fa) obese animal showing significant differences from both the other Zucker rat strains with respect to metabolite profiles. Copyright (C) 2007 John Wiley & Sons, Ltd.
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