Facile preparation of paper substrates coated with different materials and their applications in paper spray mass spectrometry

Direct application of available well-defined materials for mass spectrometry analysis represents a significant step in the combination of materials science and analytical chemistry. The present study introduces a facile vacuum filtration method for directly coating different commercially available materials onto the surface of filter paper. High sensitivity and quantitation precision have been demonstrated for different analytes including therapeutic drugs, proteins and volatile compounds in various matrices using the obtained papers as substrates for paper spray mass spectrometry.