Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 21, Issue 13, Pages 2137-2146Publisher
WILEY
DOI: 10.1002/rcm.3072
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So far, there have been only a few matrices reported for detection of polysaccharides with molecular weight higher than 3000 Daltons by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). In this work, we found that 2',4',6'-trihydroxyacetophenone (THAP) is a good matrix for MALDI time-of-flight MS analysis of polysaccharides with broad mass range. Large polysaccharides, dextrans, glycoproteins and polysialic acids have been successfully detected by MALDI-MS with THAP as matrix. Copyright (C) 2007 John Wiley & Sons, Ltd.
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