Journal
EUROPEAN JOURNAL OF CANCER
Volume 43, Issue 2, Pages 231-237Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.11.005
Keywords
polymorphism; DNA repair gene; haplotype; smoking
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Funding
- NATIONAL CANCER INSTITUTE [R01CA101844] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK007790] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021418] Funding Source: NIH RePORTER
- NCI NIH HHS [R01CA101844] Funding Source: Medline
- NIA NIH HHS [R01AG21418] Funding Source: Medline
- NIDDK NIH HHS [T32DK07790] Funding Source: Medline
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DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity. We hypothesised that DNA repair gene polymorphisms may be risk factors for prostate cancer (PC). To test this hypothesis, DNA samples from 165 cases of prostate cancer and healthy controls were analyzed by PCR-RFLP to determine the genotypic frequency of three DNA repair genes (XRCC1, XPC and XRCC7). We found that the frequency of 939Gln variant at XPC Lys939Gln was significantly lower in PC cases (OR = 0.39, P = 0.016). Haplotype analysis of XRCC1 Arg194Trp (C/T) and Arg399Gln (G/A) revealed that the frequency of the T-A haplotype was significantly higher in PC patients. This is the first report on the studies of XPC and XRCC1 Ar9194Trp polymorphisms in PC, and our present data suggest that XPC Lys939Gln and the T-A haplotype of XRCC1 Arg194Trp and Arg399Gln may be risk factors for PC in Japanese. (c) 2006 Elsevier Ltd. All rights reserved.
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