Journal
AMERICAN HEART JOURNAL
Volume 153, Issue 1, Pages 54-58Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ahj.2006.10.019
Keywords
-
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL063082, R01HL083498] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL063082, R01 HL063082-05, R01 HL063082-01, R01 HL063082-02, R01 HL063082-08, R01 HL063082-06, R01 HL063082-04, R01 HL083498, R01 HL063082-03, R01 HL063082-07A1] Funding Source: Medline
Ask authors/readers for more resources
Background The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion-deletion (ID) polymorphism interacts with pravastatin to modify the risk of coronary heart disease (CHID) and other cardiovascular end points in a large clinical trial. Methods GenHAT is an ancillary study of the ALLHAT. The ACE ID genotyped population in the lipid-lowering arm of ALLHAT included 9467 participants randomly assigned to pravastatin (n = 4741) or to usual care (n = 4726). The efficacy of pravastatin in reducing the risk of primary outcome (all-cause mortality) and secondary outcomes (fatal CHID and nonfatal myocardial infarction, cardiovascular disease [CVD] mortality, CHD, stroke, other CVD, non-CVD mortality, stroke, and heart failure) was compared between the genotype strata (dominant model ID + II vs DD, additive model II vs ID vs DD), by examining an interaction term in a Cox proportional hazards model. Results The relative risk of fatal CHID and nonfatal myocardial infarction among subjects randomized to pravastatin compared with subjects randomized to usual care was similar in subjects with the II genotype (hazard ratio [HR] 0.84, 95% CI 0.59-1.18), the ID genotype (HR 0.84, 95% CI 0.68-1.03), and the DD genotype (HR 0.99, 95% CI 0.77-1.27). Conclusions We found no evidence that the ACE ID genotype was a major modifier of the efficacy of pravastatin in reducing the risk of cardiovascular events.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available