Journal
EUROPEAN JOURNAL OF CANCER
Volume 43, Issue 2, Pages 299-307Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.09.019
Keywords
antiemetic prophylaxis; aprepitant; chemotherapy-induced nausea and vomiting; cost-effectiveness analysis; health outcomes
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Background: Chemotherapy-induced nausea and vomiting (CINV) remains a major adverse effect of cancer therapy We aimed to determine outcomes associated with use of aprepitant in outpatients undergoing highly emetogenic chemotherapy in Germany from a patient's and payer's perspective. Methods: A decision-analytic model compared an aprepitant regimen (aprepitant/ondansetron/dexamethasone) to a control regimen (ondansetron/dexamethasone) over a five days period. Clinical results and resource utilisation observed in aprepitant phase III clinical trials were assigned German unit cost data. Results: Complete response over one chemotherapy cycle was observed in 68% of patients in the aprepitant group (N = 514) compared to 48% of patients in the control group (N = 518). Patients were estimated to have gained an equivalent of 15 additional hours of perfect health per cycle (0.63 quality-adjusted life days) with aprepitant-based regimen compared to control regimen. Cost per quality-adjusted life year gained with aprepitant was estimated at Euro28,891. Conclusions: Aprepitant substantially improved CINV-related health outcomes in patients undergoing highly emetogenic chemotherapy. Incremental benefits materialised in a cost-effective fashion. (c) 2006 Elsevier Ltd. All rights reserved.
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