Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 21, Issue 4, Pages 529-535Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.2852
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The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal acceleration time-of-flight mass spectrometer (q-oaToF) are reported. The influence of eight factors is investigated: ion abundances of reference and analyte compounds, mass difference between analyte and reference compounds, quality of calibration, number of reference acquisitions averaged and TDC (time-to-digital converter) settings (resolution, Np multiplier (number of pushes correction factor), minimum number of points, i.e. minimum acquisition width which defines a peak). To extract the maximum information from as few experiments as possible, a Design of Experiment approach was used. The data will be used as a basis for developing guidance on accurate mass measurement on q-oaToF instruments. Copyright (c) 2007 John Wiley & Sons, Ltd.
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