Journal
SYNTHETIC COMMUNICATIONS
Volume 37, Issue 10, Pages 1659-1664Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701263858
Keywords
1-amidoalkyl-2-naphthols; cation-exchange resins; indion-130; multicomponent reaction
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One-pot, three-component condensation of 2-naphthol, amides/ureas, and aldehydes takes place smoothly in the presence of cation-exchange resins to afford the corresponding 1-amidoalkyl-2-naphthols in good yield. Indion-130 is found to be the best catalyst for the reaction and is recyclable. The method is simple, solvent free, and involves a short reaction time.
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