Journal
SYNTHETIC COMMUNICATIONS
Volume 37, Issue 22-24, Pages 4371-4380Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701578180
Keywords
amines; alpha-aminonitriles; carbonyl compounds; cerium(III) chloride; one-pot three-component condensation
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We report a highly efficient, one-pot, three-component condensation of carboryl compounds, amines, and TMSCN in MeCN; the reaction is significantly promoted by the catalytic amount of cerium(III) chloride at ambient temperature in excellent yields without any adverse effect on the other substituents. The method afforded an elegant alternative to the synthesis of alpha-aminonitriles. The reactions are fast and clean, and the products obtained are of high purity.
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