Journal
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
Volume 127, Issue 8, Pages 1275-1279Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/yakushi.127.1275
Keywords
Thesium Chinense Turcz; antiinflammatory activity; carrageenan-induced paw edema; ear edema; kaempferol; kaempferol-3-O-glucoside
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The ethyl acetate, chloroform extracts, and the two flavonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiinflammatory and analgesic activities. For the antiinflammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two flavonoids showed significant (p<0.05 and p<0.01) and dose-dependent antiinflammatory and analgesic activity. The chloroform extract was inactive in the assay.
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