Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 117, Issue 1, Pages 50-59Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI30082
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Funding
- NIAAA NIH HHS [AA11999, R21 AA015781, P50 AA011999, AA15781] Funding Source: Medline
- NIDDK NIH HHS [R21 DK073909, P30 DK056339, DK52951, DK47918, DK73909, R56 DK052951, R01 DK052951, DK56339, R01 DK047918] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R21DK073909, P30DK056339, R01DK052951, R01DK047918] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R21AA015781, P50AA011999] Funding Source: NIH RePORTER
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Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with their hepatic counterparts, studies of which have helped further our understanding of PaSC biology. Activation of PaSCs induces them to proliferate, to migrate to sites of tissue damage, to contract and possibly phagocytose, and to synthesize ECM components to promote tissue repair. Sustained activation of PaSCs has an increasingly appreciated role in the fibrosis that is associated with chronic pancreatitis and with pancreatic cancer. Therefore, understanding the biology of PaSCs offers potential therapeutic targets for the treatment and prevention of these diseases.
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