Journal
THROMBOSIS RESEARCH
Volume 120, Issue -, Pages S5-S9Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2007.03.011
Keywords
shear stress; platelet adhesion; platelet activation; platelet aggregation; thrombus formation; von Willebrand factor; VWF
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL078784, P01HL031950, R01HL042846, R37HL042846, R01HL075736, U01HL080718] Funding Source: NIH RePORTER
- NHLBI NIH HHS [U01 HL080718, HL-75736, R37 HL042846-19, HL-78784, P01 HL078784-050004, HL-80718, R01 HL075736-04, R37 HL042846, R01 HL042846, P01 HL031950-219005, P01 HL031950, HL-31950, P01 HL031950-210011, P01 HL078784, R01 HL075736, HL-42846, U01 HL080718-04] Funding Source: Medline
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Von Wittebrand factor (VWF) is a large multimeric glycoprotein produced in endotheliat cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF mediates adhesion and aggregation of platelets at sites of vascular injury, processes that are critical for both haemostasis and thrombosis. Thrombus formation involves complex events that are influenced by different environmental conditions. Progress in understanding the structure and function of VWF and the mechanisms that underlie its interactions with platelets has led to important insight into the differentiation between normal haemostasis and pathological arterial thrombosis. The conventional view of signalling-induced platelet aggregation has recently been extended to include activation-independent aggregation. A novel mechanism has been demonstrated for initiating thrombus formation under high haemodynamic forces that involves alpha(IIb)beta(3)-independent platelet aggregation at the interface between immobilised and soluble VWF. This VWF-mediated process may be a key determinant of platelet accumulation in stenotic arteries leading to acute thrombotic occlusion. (c) 2007 Elsevier Ltd. All rights reserved.
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