Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 81, Issue 1, Pages 137-143Publisher
WILEY
DOI: 10.1189/jlb.0806542
Keywords
cecal ligation and puncture; lipopolysaccharide; rodents
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Funding
- NHLBI NIH HHS [HL-31963] Funding Source: Medline
- NIGMS NIH HHS [GM-29507, GM-61656] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL031963] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM029507, R01GM029507, R01GM061656] Funding Source: NIH RePORTER
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Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy in septic humans. We describe the short-comings of the animal models and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsis.
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