Journal
CELL CYCLE
Volume 6, Issue 1, Pages 8-10Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.6.1.3633
Keywords
Oct-3/4; POU; differentiation; ES cell; cardiogenesis; epigenetic; miRNA
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Oct-3/4 encoded by Pou5f1 has been longwise recognised as a gatekeeper for embryonic stem (ES) cell pluripotency. Recently, it was suggested that Oct-3/4 one of the earliest transcription factor of the embryo might feature some functions in differentiation of cell lineages. We recently uncovered a key role of Oct-3/4 in both ES cell specification toward a cardiac lineage and in mesodermal commitment of the embryonic epiblast. Our findings demonstrated a gene dosage effect of Oct-3/4, a factor at the cross-road between cell self-renewal and cell lineage specification. What is the genetic and/or epigenetic mechanism underlying this process is still questionable. The extraview presents some hypotheses that might account for the pleictropic dose-dependent functions of Oct-3/4.
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