Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 71, Issue 1, Pages 242-245Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.60441
Keywords
ATP-binding cassette (ABC) transporter; berberine; multidrug resistance protein (MDR); multidrug resistance associated protein (MRP); transport
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To examine whether human ATP-binding cassette (ABC) transporters play a role in the detoxification of plant alkaloid berberine, we investigated berberine transport using multidrug resistance protein1 (MDRI) and multidrug resistance-associated proteinl (MRP1). Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.
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