4.3 Article

Isocyanide-based multicomponent synthesis of functionalized 2,6-dioxohexahydropyrimidines in 1 m aqueous glucose

Journal

SYNTHETIC COMMUNICATIONS
Volume 37, Issue 15, Pages 2593-2599

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701462922

Keywords

acetylenedicarboxylates; aqueous glucose; dimethylurea; hexahydropyrimidine; isocyanide; three-component reaction

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An effective route to novel 2,6-dioxohexahydropyrimidines is described. This involves reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates in the presence of N, N'-dimethylurea in 1M aq. glucose.

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