Journal
CANADIAN MEDICAL ASSOCIATION JOURNAL
Volume 182, Issue 10, Pages E472-E478Publisher
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/cmaj.091716
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- Canadian Institutes of Health Research (CIHR)
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Background We established a program of research to improve the development, reporting and evaluation of practice guidelines. We assessed the construct validity of the items and user's manual in the beta version of the AGREE II. Methods We designed guideline excerpts reflecting high- and low-quality guideline content for 21 of the 23 items in the tool. We designed two study packages so that one low-quality and one high-quality version of each item were randomly assigned to each package. We randomly assigned 30 participants to one of the two packages. Participants reviewed and rated the guideline content according to the instructions of the user's manual and completed a survey assessing the manual. Results In all cases, content designed to be of high quality was rated higher than low-quality contents in 18 of 21 cases, the differences were significant (p < 0.05). The manual was rated by participants as appropriated easy to used and helpful in differentiating guidelines of varying quality, with all scores above the mid-point of the sevene-point scale. Considerable feedback was offered on how the items and manual of the beta-AGREE II could be improved. Interpretation The validity of the items was established and the user's manual was rated as highly useful by users. We used these results and those of our study presented in part 1 to modify the items and user's manual. We recommend AGREE II (available at www.agreetrust.org) as the revised standard for guideline development, reporting and evaluation.
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