Journal
HAEMATOLOGICA
Volume 92, Issue 9, Pages 1266-1267Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11379
Keywords
lactadherin; sickle cell anemia; phosphatidyl-serine; endothelial adhesion
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Funding
- Veterans Affairs Research Service
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Increased exposure of sickle red blood cells to phosphatidylserine promotes its adhesion to the endothelium. A monoclonal antibody to lactadherin, a phosphatidylserine binding protein, inhibits sickle cell adhesion to histamine-stimulated endothelial cells in flowing blood. Added lactadherin enhances the adhesion via the integrin alpha V beta 3. These results indicate that lactadherin can mediate phosphatidylserine-expressing sickle cell adhesion to the endothelium.
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