Journal
HAEMATOLOGICA
Volume 92, Issue 9, Pages 1268-1269Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11202
Keywords
AML; FLT3 mutation; NPM1 mutation; minimal residual disease
Categories
Funding
- COFIN 2005 (Myelodisplastic syndromes: pathogenetic models and promise of new therapies)
- COFIN 2003 (Molecular therapy of leukemias)
- FIRB 2001
- University of Bologna
- Italian Association for Cancer Research (A.I.R.C.)
- Italian National Research Council (C.N.R)
- Fondazione Del Monte of Bologna e Ravenna (Italy)
- A.I.L. grants
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NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.
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