Journal
HAEMATOLOGICA
Volume 92, Issue 4, Pages 574-575Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10891
Keywords
mantle cell lymphoma; MDM2 expression; survival; SNP309
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Funding
- Interdisciplinary Center for Clinical Research (IZKF), University of Wurzburg
- European Grant [503351]
- Lymphoma Research Foundation (LRF), USA
- grant CICYT by the Spanish Ministry of Science [SAF 05/5855]
- Spanish Ministry of Education and Science (MEC)
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We here show that increased expression of MDM2, a negative regulator of p53, correlates with inferior survival in a series of 43 mantle cell lymphomas. MDM2 overexpression is associated with copy number gains of the MDM2 locus in single tumors, but not with the recently reported MDM2 promoter SNP309.
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