Journal
HAEMATOLOGICA
Volume 92, Issue 4, Pages 570-571Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10770
Keywords
doxorubicin; carrier erythrocytes; pharmacokinetics; lymphoma
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Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.
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