Journal
STEM CELLS
Volume 25, Issue 3, Pages 589-601Publisher
WILEY
DOI: 10.1634/stemcells.2006-0623
Keywords
heart; confocal and light microscopy; mitosis; chimerism; bone marrow cell transdifferentiation enhanced green fluorescent protein autofluorescence
Categories
Funding
- NHLBI NIH HHS [HL 68088, HL 65577, HL 55757, HL 66923, HL 38132, HL 76794, HL 65573, HL 70897, HL 75480] Funding Source: Medline
- NIA NIH HHS [AG 15756, AG 17042, AG 23071] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL066923, R37HL055757, R01HL075480, R01HL065577, R01HL038132, R01HL068088, R01HL076794, R01HL055757, R01HL070897, R01HL065573] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG023071, R01AG015756, R01AG017042] Funding Source: NIH RePORTER
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This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. Although great enthusiasm was created by the possibility of reconstituting the damaged heart, the opponents of this new concept of cardiac biology have interpreted most of the findings supporting this possibility as the product of technical artifacts. This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells.
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