Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 3, Pages 342-346Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np060484y
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Funding
- FOGARTY INTERNATIONAL CENTER [U01TW000313, F15TW000313] Funding Source: NIH RePORTER
- FIC NIH HHS [TW 000313, U01 TW000313-07, U01 TW000313] Funding Source: Medline
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Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC50 = 0.13 mu M) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 mu M) was the most potent of the new compounds.
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