Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 23, Issue 1, Pages 116-122Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2006.0117
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Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [G12RR003050] Funding Source: NIH RePORTER
- NCRR NIH HHS [G12 RR003050, G12 RR03050-19, G12 RR03050] Funding Source: Medline
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Antibodies to HERV-K antigens have been linked to HIV-1 infection and expression of HERV-K proteins generates T-cell cytotoxic responses in many cancers. HERV-K RNA and protein abundance was measured in HIV-1-infected and control cells. In vitro exposure of HIV-1 laboratory-adapted and primary isolates on U87MG cells increased the expression of HERV-K RNA in a dose-dependent manner. HERV-K RNA and protein burdens were significantly increased in HIV-1-producing H9 cell lines compared to H9 cells. The expression of HERV-K was synergistically increased in HIV-1-infected PBMCs after stimulation with PMA/ionomycin. Furthermore, the expression of HERV-K in PBMCs, and particularly in CD4(+) T cells, was higher in HIV- 1 patients compared to control subjects. The expression of HERV-K might be related to HIV-1 pathogenesis and AIDS-associated cancers.
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