Journal
THROMBOSIS AND HAEMOSTASIS
Volume 97, Issue 1, Pages 119-123Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH06-03-0141
Keywords
cancer; microparticles; tissue factor; hemostasis; platelets
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The pathogenesis of hypercoagulability in cancer is not entirely understood. We hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF+ MPs) are increased and associated with hemostatic system activation. In 20 patients with advanced colorectal cancer and in 20 age- and sex-matched controls, number and cellular origin of TF+ MPs were determined in plasma by flow cytometry. D-dimer was determined as an indicator of hemostatic system activation. Compared to controls, the median (interquartile range) number of TF+ MPs was two-fold higher in cancer patients: 25.9 (15.4 - 42.0) x 10(3)/ml plasma versus 13.1 (11.9 - 19.7) x 10(3)/ml plasma, p = 0.007. This was mainly due to a higher amount of TF+ MPs from platelets (13.4 [5.0 - 17.4] x 10(3)/ml plasma vs. 5.8 [4.5 - 7.5] x 10(3)/ml plasma, p = 0.017). TF+ MPs correlated with D-dimer (p = 0.48, p = 0.002). High levels of TF+ MPs in cancer patients and their correlation with D-climer suggest that TF+ MPs might be involved in hemostasis activation in cancer patients.
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