Journal
FREE RADICAL RESEARCH
Volume 41, Issue 1, Pages 25-37Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600939734
Keywords
isoprostanes; phytoprostanes; lipid peroxidation; intralipid; soybean oil; olive oil
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Phytoprostanes (PP) are autoxidation products of alpha-linolenate that are present in all plant tissues. Several classes of PP with a prostaglandin (PG) F-1-, E-1-, A(1)-and B-1-like structure were identified and quantified by gas chromatography-mass spectrometry in vegetable oils and parenteral nutrition (intralipid). High levels of PP (0.09 up to 99 mg/l) were found even in apparently fresh vegetable oils. After oral consumption of olive or soybean oil, PPF1 were absorbed, found to circulate in plasma in conjugated form and excreted in free form into urine. Evidence is emerging that certain PP, such as the PPE1, may modulate the function of immune cells in a PG-like fashion. Here, we show that PPA(1)-and deoxy-PPJ(1) display potent antiinflammatory and apoptosis inducing activities similar to PGA(1) and deoxy-PGJ(2). Results of this study indicate that PP are novel, biologically active lipids in plant nutrition.
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